We are interested in the communication between myelinating oligodendrocytes and neurons in the central nervous system. In particular, we investigate the role of extracellular vesicles (exosomes), which are transferred from the oligodendrocyte to the neuron and exert multifaceted effects on target neurons.
Key techniques: Cell culture, immunocyto-/histochemistry, protein biochemistry, RNA analysis
Research system/organism: Mouse
- Frühbeis C.*, Fröhlich D.*, Kuo, W.P., Amphornrat J., Thilemann S., Saab A., Kirchhoff F., Möbius W., Nave K.-A., Schneider A., Simons M., Klugmann M., Trotter J., and Krämer-Albers E.-M. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLOS Biol., 2013, 11(7)
- Frühbeis C., Fröhlich D., Kuo W. P, and Krämer-Albers E.-M. Extracellular vesicles as mediators of neuron-glia communication. Front. Cell. Neurosci., 2013, 7:182
- Frühbeis C., Fröhlich D., and Krämer-Albers E.-M. Emerging roles of exosomes in neuron-glia communication. Front. Physio., 2012, 3:119
- Krämer-Albers E.-M. and Frühbeis C. Delivery on call: exosomes as “care packages” from glia cells for stressed neurons. E-Neurofo