Dr. Carsten Frühbeis


Dr. Carsten Frühbeis
Molecular Cell Biology, JGU
Bentzelweg 3, 55128 Mainz
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Research Interests

We are interested in the communication between myelinating oligodendrocytes and neurons in the central nervous system. In particular, we investigate the role of extracellular vesicles (exosomes), which are transferred from the oligodendrocyte to the neuron and exert multifaceted effects on target neurons.

Key techniques: Cell culture, immunocyto-/histochemistry, protein biochemistry, RNA analysis

Research system/organism: Mouse

Five Most Relevant Publications
  1. Frühbeis C.*, Fröhlich D.*, Kuo, W.P., Amphornrat J., Thilemann S., Saab A., Kirchhoff F., Möbius W., Nave K.-A., Schneider A., Simons M., Klugmann M., Trotter J., and Krämer-Albers E.-M. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLOS Biol., 2013, 11(7)
  2. Frühbeis C., Fröhlich D., Kuo W. P, and Krämer-Albers E.-M. Extracellular vesicles as mediators of neuron-glia communication. Front. Cell. Neurosci., 2013, 7:182
  3. Frühbeis C., Fröhlich D., and Krämer-Albers E.-M. Emerging roles of exosomes in neuron-glia communication. Front. Physio., 2012, 3:119
  4. Krämer-Albers E.-M. and Frühbeis C. Delivery on call: exosomes as “care packages” from glia cells for stressed neurons. E-Neurofo