Dr. Petra Beli

Petra Beli









Dr. Petra Beli
Emmy Noether Group Leader
Institute of Molecular Biology (IMB)
Ackermannweg 4, 55128 Mainz
Web page

Research Interests

The integrity of the human genome is constantly challenged by external and internal insults that can induce a variety of DNA lesions. Human cells have evolved complex signalling pathways that respond to DNA damage and coordinate DNA repair. We are interested in identifying the mechanisms underlying the cellular response to DNA damage. In particular, we are investigating the role of protein-protein interactions and posttranslational modifications of proteins in this process. Towards these goals, we employ quantitative mass spectrometry-based proteomics as well as biochemical and cell biological methods.

Key techniques: Mass spectrometry-based proteomics

Research system/organism: Human cell lines

Five Most Relevant Publications
  1. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. (2012) Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat Cell Biol.14(10):1089-98.
  2. Wagner SA, Beli P, Weinert BT, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch CH, Choudhary C. (2012) Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Mol Cell Proteomics. 11(12):1578-85.
  3. Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C. (2011) Proteomic investigations reveal a role of THRAP3 in DNA damage response. Mol Cell. 46(2):212-25.
  4. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. (2011) A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics.10(10):M111.013284.
  5. Beli P, Mascheroni D, Xu D and Innocenti M. (2008) WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Nat Cell Biol. 10(7):849-57.