The integrity of the human genome is constantly challenged by external and internal insults that can induce a variety of DNA lesions. Human cells have evolved complex signalling pathways that respond to DNA damage and coordinate DNA repair. We are interested in identifying the mechanisms underlying the cellular response to DNA damage. In particular, we are investigating the role of protein-protein interactions and posttranslational modifications of proteins in this process. Towards these goals, we employ quantitative mass spectrometry-based proteomics as well as biochemical and cell biological methods.
Key techniques: Mass spectrometry-based proteomics
Research system/organism: Human cell lines
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