My main interests are the physiology and pathophysiology of respiration and mechanical ventilation, especially within the acute respiratory distress syndrome (ARDS) or injured lung. Furthermore, I`m focussing on the complex and fascinating cross-talk between injured organs (i.e. lung and brain) in the development of multiple organ failure, and novel therapeutic interventions or organoprotective strategies. The centre of my laboratory is an experimental, but translational approach, which we create by use of clinical-like porcine models.
Key techniques: Large animal models, ARDS, sepsis, multiple inert gas elimination, electrical impedance tomography, respiratory and real-time monitoring
Research system/organism: Pig (sus scrofa domestica)
- The PROVE Network Investigators for the Clinical Trial Network of the European Society of Anaesthesiology. (Hartmann E; collaborating authorship indicated in supplement)
High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. Lancet 2014; Epub ahead of print 2014 May 30.
- Hartmann EK, Duenges B, Baumgardner JE, Markstaller K, David M
Correlation of thermodilution-derived extravascular lung water and ventilation/perfusion-compartments in a porcine model. Intensive Care Med 2013; 39(7): 1313-7.
- Hartmann EK, Boehme S, Duenges B, Bentley A, KLein KU, Kwiecien R, Shi C, Szczyrba M, David M, Markstaller K
An inhaled tumor necrosis factor-alpha-derived TIP peptide improves the pulmonary function in experimental lung injury. Acta Anaesthesiol Scand. 2013; 57(3):334-41.
- Klein KU, Boehme S, Hartmann EK, Szczyrba M, Heylen L, Liu T, David M, Werner C, Markstaller K, Engelhard K
Transmission of arterial oxygen partial pressure oscillations to the cerebral microcirculation in a porcine model of acute lung injury caused by cyclic recruitment and derecruitment. Br J Anaesth. 2013; 110(2):266-73.
- Hartmann EK, Boehme S, Bentley AH, Duenges B, Klein KU, Elsaesser A, Baumgardner JE, David M, Markstaller K
Influence of respiratory rate and end-expiratory pressure variation on cyclic alveolar recruitment in an experimental lung injury model. Crit Care 2012; 16(1): R8.