Jun.-Prof. Dr. Carsten Deppermann

Jun.-Prof. Dr. Carsten Deppermann
Assistant Professor (Juniorprofessor)
Center for Thrombosis and Hemostasis (CTH), Mainz University Medical Center
Raum 3.008, Geb. 708, Langenbeckstraße 1, 55131 Mainz

Research Interests

Platelets are small, anucleate cells that patrol the vasculature and contribute to hemostasis and thrombosis. However, there is accumulating evidence that platelets also interact with and regulate cells of the (innate) immune system and contribute to thromboinflammation.

We are currently employing intravital microscopy, tissue clearing, primary cell culture, flow cytometry and other state-of-the-art techniques to understand the complex interplay between platelets and the innate immune system in the liver, kidney and intestine under (patho)physiologic conditions. We are also studying the mechanisms through which platelet clearance in health and disease feeds back to platelet production by megakaryocytes in the bone marrow.

Key techniques: flow cytometry, microscopy (confocal, intravital), tissue clearing, platelet analyses

Research system/organism: Mouse

Five Most Relevant Publications
  1. Zindel J, Peiseler M, Hossain M, Deppermann C, Lee WY, Haenni B, Zuber B, Deniset JF, Surewaard BGJ, Candinas D, Kubes P. Primordial GATA6 macrophages function as extravascular platelets in sterile injury. Science 371(6533):eabe0595 (2021) https://doi.org/10.1126/science.abe0595
  2. Deppermann C*, Peiseler M*, Zindel J, Zbytnuik L, Lee WY, Pasini E, Baciu C, Matelski J, Lee Y, Kumar D, Humar A, Surewaard B, Kubes P and Bhat M. Tacrolimus impairs Kupffer cell capacity to control bacteremia: why transplant recipients are susceptible to infection. Hepatology (2020) https://doi.org/10.1002/hep.31499 *equal contribution
  3. Deppermann C, Kratofil RM, Peiseler M, David BA, Zindel J, Castanheira FVES, van der Wal F, Carestia A, Jenne CN, Marth JD and Kubes P. Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets. J. Exp. Med. 217(4): e20190723 (2020) https://doi.org/10.1084/jem.20190723
  4. Deppermann C, Kraft P, Volz J, Schuhmann MK, Beck S, Wolf K, Stegner D, Stoll G and Nieswandt B. Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice. Blood 129(12): 1702-07 (2017) https://doi.org/10.1182/blood-2016-12-750711
  5. Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming S, Nurden A, Eckes B, Stoll G, Stegner D and Nieswandt B. Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice. J. Clin. Invest. 123(8): 3331-42 (2013) https://doi.org/10.1172/JCI69210